With the world’s population expected to exceed nine billion by 2050, scientists are working to develop new ways to meet rising global demand for food, energy, and water without increasing the strain on natural resources and the environmental pressure. Organizations including the World Bank, and the U.N. Food and Agriculture Organization, as well as the EU F2F and Green Deal strategies are calling for more innovation to address the challenges of the agri-food sector. The development of nano-based techniques in agriculture has been started very recently; they will be implemented within the evolving science of precision agriculture, in which farmers use technology to target their use of water, fertilizer, plant protection products and other inputs. A second, broad potential application concerns the issues of reduction and valorization of agri-food wastes. The introduction of nanotechnologies in agriculture still needs deepen basic and applied knowledge, however several promising results were achieved, so far. A huge development is taking place in this sector, therefore nanotech applications currently under development will soon be overtaken by other ideas that are expected to contribute to solve several issues in the field of sustainable agriculture. NanoInnovation 2025 hosts workshop “Nano-enabled Agriculture” co-organized by the Universities of Parma, Tuscia and Udine. The workshop will be the forum for discussing the perspective of nanotechnologies in the primary sector among the stakeholders and scientific research.