This session will explore the development of smart and functional nanomaterials for advanced drug and gene delivery, biosensing, and phototherapeutic strategies. Talks will cover biomimetic nanoparticles, hybrid platforms, and responsive nanostructures designed for selective disease targeting and real-time diagnostic integration. Emphasis will be placed on material design, functionalization, and in vivo behavior, highlighting applications in cancer therapy, immune modulation, and personalized nanomedicine.