The symposium on Antimicrobial Nanoparticles as future challenge in management of recurrent/resistant Biofilm-Associated Infection is a targeted thematic session dedicated to topics which fall in the framework of the PRIN 2022 project entitled “Future challenges in management of recurrent/resistant Infection: development of antimicrobial Nanoparticulate systems and physical-chemical investigation of their Interactions with biofilm-associated infection” (FINI), CUP: J53D23008880006, PNRR – Mission 4, Component 2, Investment 1.1 – PRIN 2022 Call for Proposals - Directorial Decree No. 104 of 02-02-2022, funded by the European Union - Next Generation EU.

In this session, featuring presentations and interactive discussions that delve into the current challenges in the design and characterization of novel therapeutic systems based on antimicrobial nanoparticles (NPs), capable of eradicating biofilm-associated infections without cytotoxicity and side effects, will be addressed. Particular emphasis will be paid to the multiple viewpoints related to most advanced drug-loaded nanoplatforms employed for the eradication of biofilms produced by selected pathogen microorganisms, passing from technological aspects and design to their comprehensive physicochemical and morphological characterization.

Topics will encompass, in particular, synthesis techniques, pre-formulation studies, structural/dynamical characterizations and anti-bacterial/anti-biofilm assays, of newly synthesized anti-biofilm nanoparticulate systems, with the aim to offer a comprehensive scenario of the current advancements and targeted delivery mechanisms which propel their efficacy against resistant microbial communities.

The ultimate goal will be to foster a deeper knowledge of almost unknown processes related to biofilm-nanoplatform interactions and to provide a comprehensive overview of the state-of-art in view of developing novel nanoparticulate carriers, loading antimicrobial and natural anti-inflammatory agents, for innovative multi-drug therapies.