The evolution of RNA-based therapeutics—ranging from mRNA to siRNA and gene editing technologies—led to a critical demand for delivery systems that ensure stability, specificity and controlled release. This session focuses on polymeric platforms as versatile and tunable carriers for RNA molecules in therapeutic applications. Polymeric systems, including both natural and synthetic polymers, offer distinct advantages such as structural flexibility, chemical modifications and responsiveness to physiological stimuli. These features allow for engineering of delivery systems capable of overcoming biological barriers, enhancing cellular uptake and reducing off-target effects. Through discussion of recent advancements in polymer chemistry, nanostructure design and translational performance, the session will explore how these systems are being optimized to meet the complex requirements of RNA-based therapies. Special attention will be given to clinical potential, biodegradability, and scalability for future pharmaceutical development.