Emerging strategies in gene delivery are increasingly turning to bioinspired platforms that mimic or repurpose natural carriers such as exosomes, extracellular vesicles, and hybrid nanostructures. This session explores how these biologically derived or biomimetic systems are redefining the landscape of genetic material transport, offering promising alternatives to conventional synthetic vectors. Leveraging the inherent advantages of natural carriers—such as biocompatibility, low immunogenicity, and innate targeting capabilities—bioinspired platforms enable more effective and precise delivery of nucleic acids, including mRNA, siRNA, and CRISPR components. Hybrid systems that combine biological and synthetic elements further expand the possibilities for customization and functionalization. The session will highlight recent advances in the engineering, functionalization, and translational application of these platforms, with a focus on their potential to address current limitations in gene therapy, vaccine development, and molecular medicine.